Choline Acetyltransferase Antibody | 50-265

Choline Acetyltransferase Antibody | 50-265 | Gentaur UK, US & Europe Distribution

Host: Goat

Reactivity: Human, Mouse, Rat, Goat, Chicken

Homology: N/A

Immunogen: Native choline acetyltransferase purified from human placenta.

Research Area: Neuroscience

Tested Application: WB, IHC

Application: N/A

Specificiy: Specific for the ~ 70k choline acetyltransferase protein

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 70

Validation: N/A

Isoform: N/A

Purification: Affinity Purified

Clonality: Polyclonal

Clone: N/A

Isotype: N/A

Conjugate: Unconjugated

Physical State: Liquid

Buffer: N/A

Concentration: N/A

Storage Condition: Choline Acetyltransferase antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.

Alternate Name: N/A

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999) . Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993) . It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999) .