CHRDL2 Polyclonal Antibody | BS65872

CHRDL2 Polyclonal Antibody | BS65872 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Cow,Sheep,

Application: WB,

Application Range: WB=1:500-2000

Background: CHRDL2 is a novel chordin like protein that can act as a BMP antagonist. A member of the chordin family of proteins, it contains a signal peptide and three CR (cysteine-rich repeat) domains. When expressed as a recombinant protein it is secreted and binds to activin A, but not to BMP-2, -4, -6. Differential expression has been detected in developing chondrocytes, myoblasts, osteoblasts, and osteoarthritic joints. Complex alternative splicing of CHRDL2 potentially results in distinct isoforms that differ at their C termini, in the expression of signal peptide, and in the content of CR domains. CHRDL2 was originally characterized as a novel protein exclusively expressed in breast, lung, and colon tumors.

Storage & Stability: Store at 4°C short term. Aliquot and store at -45°C long term. Avoid freeze-thaw cycles.

Specificity: CHRDL2 Polyclonal Antibody detects endogenous levels of CHRDL2 protein.

Molecular Weight: ~45kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: BNF1; Breast tumor novel factor 1; CHL2; chordin like 2; Chordin like protein 2 precursor; Chordin related protein 2; CRDL2_HUMAN.

Immunogen: KLH conjugated synthetic peptide derived from human CHRDL2:351-429/429

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: