CHRNA2 Polyclonal Antibody | E-AB-16340

CHRNA2 Polyclonal Antibody | E-AB-16340 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: ACHA2, AChR, Cholinergic receptor nicotinic alpha 2, Chrna2, Neuronal acetylcholine receptor protein subunit alpha 2, Neuronal acetylcholine receptor subunit alpha-2

Application: WB, IHC, ELISA

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Neuroscience

Background: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.

Concentration: 0.5 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human CHRNA2

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:25-1:100

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 60 kDa

Molecular Weight(Observed): N/A