Description
Cell-permeable. A potent, competitive, and reversible antagonist of the orphan receptor GPR35 (Ki = 12.8 nM). Prevents the GPR35-mediated increase in ERK1/2 phosphorylation and β-arrestin recruitment induced by pamoic acid.
CID 2745687 is a potent, competitive, and reversible antagonist of the orphan receptor GPR35 (Ki = 12.8 nM). Prevents the GPR35-mediated increase in ERK1/2 phosphorylation and β-arrestin recruitment induced by pamoic acid.
Alternate Name/Synonyms: Methyl -5-((2-t-butylcarbamothioyl)hydrazono)methyl)-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylate
Appearance: White solid
Formulation: N/A
CAS Number: 264233-05-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₉F₂N₅O₂S
Molecular Weight: 395.43
Cell-Permeable?: Yes
Purity: ≥95% by HPLC
Solubilities: DMSO (~ 100 mM) or Ethanol (~ 10 mM)
Handling: Protect from light and air
Country of Origin: USA
Tag Line: A potent and reversible antagonist of the orphan receptor GPR36
MDL Number: N/A
PubChem CID: 9581011
SMILES: CC(C)(C)NC(=S)NN=CC1=C(C=NN1C2=C(C=C(C=C2)F)F)C(=O)OC
InChi: InChI=1S/C17H19F2N5O2S/c1-17(2,3)22-16(27)23-20-9-14-11(15(25)26-4)8-21-24(14)13-6-5-10(18)7-12(13)19/h5-9H,1-4H3,(H2,22,23,27)/b20-9+
InChi Key: CYNLZIBKERMMOA-AWQFTUOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
48 months |
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