CID-755673 | 2660

CID-755673 is a selective small molecule inhibitor of protein kinase D (PKD) (IC₅₀s = 182, 280, 227 nM for PKD1, 2, and 3, respectively). It exhibits higher selectivity for PKD over Akt, polo-like kinase 1, CDK activating kinase, CAMKII and three different PKC isoforms (IC₅₀s range from 15 to > 50 µM). At 25 µM, CID-755673 has been shown to inhibit prostate cancer cell proliferation, cell migration, and invasion.

CID-755673 is a selective small molecule inhibitor of protein kinase D (PKD) (IC₅₀s = 182, 280, 227 nM for PKD1, 2, and 3, respectively). It exhibits higher selectivity for PKD over Akt, polo-like kinase 1, CDK activating kinase, CAMKII and three different PKC isoforms (IC₅₀s range from 15 to > 50 µM).

2660 | CID-755673 DataSheet

Alternate Name/Synonyms: 2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one

Appearance: Brown solid

Formulation: N/A

CAS Number: 521937-07-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₁₁NO₃

Molecular Weight: 217.22

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml) or EtOH (~ 5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective protein kinase D (PKD) inhibitor

MDL Number: N/A

PubChem CID: 755673

SMILES: C1CC2=C(C(=O)NC1)OC3=C2C=C(C=C3)O

InChi: InChI=1S/C12H11NO3/c14-7-3-4-10-9(6-7)8-2-1-5-13-12(15)11(8)16-10/h3-4,6,14H,1-2,5H2,(H,13,15)

InChi Key: AACFPJSJOWQNBN-UHFFFAOYSA-N