Cidofovir | B2682

Cidofovir is a selective inhibitor of viral DNA synthesis through the selective inhibition of viral DNA polymerase. In vitro, cidofovir is converted to cidofovir diphosphate which incorporates into viral DNA, selectively inhibiting CMV replication and CMV DNA synthesis with IC50 values of 0.1 μM. Cidofovir has significantly long-lasting antiviral action because of the long half-life of its metabolites whose cellular uptake is slow due to the presence of the negatively charged phosphonate group.

Cidofovir is a selective inhibitor of viral DNA synthesis through the selective inhibition of viral DNA polymerase. In vitro, cidofovir is converted to cidofovir diphosphate which incorporates into viral DNA, selectively inhibiting CMV replication and CMV DNA synthesis with IC50 values of 0.1 μM. Cidofovir has significantly long-lasting antiviral action because of the long half-life of its metabolites whose cellular uptake is slow due to the presence of the negatively charged phosphonate group.

B2682 | Cidofovir DataSheet

Alternate Name/Synonyms: P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-phosphonic acid,GS-0504,HPMPC,Vistide

Appearance: White to off-white solid

Formulation:

CAS Number: 113852-37-2

Structure Available?: TRUE

Peptide sequence: N/A

Salt Form: FALSE

Molecular Formula: C₈H₁₄N₃O₆P

Molecular Weight: 279.19

Cell-Permeable?: TRUE

Purity: ≥95%

Solubilities: ~ 2 mg/ml Other Solvents

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An antiviral agent

MDL Number: MFCD17215968

PubChem CID: 60613

SMILES: C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O

InChi: InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1

InChi Key: VWFCHDSQECPREK-LURJTMIESA-N