Cilofexor | B2604

Cilofexor (GS-9674), is a nonsteroidal bile acid farnesoid X receptor (FXR) agonist. It improves markers of cholestasis and liver injury in patients with PSC. PSC is an incurable rare chronic liver disease triggered by environmental, immunobiologic and genetic underpinnings resulting in imbalance in bile acids homeostasis that leads to cholestasis with inflammation and fibrosis of the bile ducts.

Cilofexor (GS-9674), is a nonsteroidal bile acid farnesoid X receptor (FXR) agonist. It improves markers of cholestasis and liver injury in patients with PSC. PSC is an incurable rare chronic liver disease triggered by environmental, immunobiologic and genetic underpinnings resulting in imbalance in bile acids homeostasis that leads to cholestasis with inflammation and fibrosis of the bile ducts.

B2604 | Cilofexor DataSheet

Alternate Name/Synonyms: GS-9674, GS9674, GS 9674, 2-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxyazetidin-1-yl)isonicotinic acid

Appearance: White to off-white solid

Formulation:

CAS Number: 1418274-28-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₂₂Cl₃N₃O₅

Molecular Weight: 586.85

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A farnesoid X receptor (FXR) agonist

MDL Number:

PubChem CID: 71228883

SMILES: C1CC1C2=C(C(=NO2)C3=C(C=CC=C3Cl)Cl)COC4=CC(=C(C=C4)C5(CN(C5)C6=NC=CC(=C6)C(=O)O)O)Cl

InChi: InChI=1S/C28H22Cl3N3O5/c29-20-2-1-3-21(30)24(20)25-18(26(39-33-25)15-4-5-15)12-38-17-6-7-19(22(31)11-17)28(37)13-34(14-28)23-10-16(27(35)36)8-9-32-23/h1-3,6-11,15,37H,4-5,12-14H2,(H,35,36)

InChi Key: KZSKGLFYQAYZCO-UHFFFAOYSA-N