Cimetidine | B3315

Cimetidine is a potent histamine H2 receptor antagonist (Ki = 0.6 μM). It also acts as an inverse agonist, inhibiting basal cAMP production in CHO cells expressing recombinant H2 receptors (IC50 = 1.2 μM). Cimetidine inhibits histamine-induced acid secretion from isolated bullfrog gastric mucosa (IC50 = 16 μM).

Cimetidine is a potent histamine H2 receptor antagonist (Ki = 0.6 μM). It also acts as an inverse agonist, inhibiting basal cAMP production in CHO cells expressing recombinant H2 receptors (IC50 = 1.2 μM). Cimetidine inhibits histamine-induced acid secretion from isolated bullfrog gastric mucosa (IC50 = 16 μM).

B3315 | Cimetidine DataSheet

Alternate Name/Synonyms: SKF 92334 NSC 335308 N-cyano-N''-methyl-N'-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]-guanidine

Appearance: White to off-white solid

Formulation:

CAS Number: 51481-61-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₁₆N₆S

Molecular Weight: 252.34

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >30 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A histamine H2 receptor antagonist

MDL Number: MFCD00133296

PubChem CID: 2756

SMILES: CN/C(NC#N)=N\CCSCC1=C(C)NC=N1

InChi: InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)

InChi Key: AQIXAKUUQRKLND-UHFFFAOYSA-N