Cladribine | B2037

Cladribine is an adenosine deaminase inhibitor. It is phosphorylated by deoxycytidine kinase, resulting in its intracellular accumulation and inhibition of ribonucleotide reductase. Cladribine displays selective cytotoxicity against both proliferating and non-dividing lymphocytes. Also displays immunosuppressive activity.

Cladribine is an adenosine deaminase inhibitor. It is phosphorylated by deoxycytidine kinase, resulting in its intracellular accumulation and inhibition of ribonucleotide reductase. Cladribine displays selective cytotoxicity against both proliferating and non-dividing lymphocytes. Also displays immunosuppressive activity.

B2037 | Cladribine DataSheet

Alternate Name/Synonyms: 2-Chloro-2'-deoxy-adenosine; NSC105014; RWJ 26251

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 4291-63-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₁₂ClN₅O₃

Molecular Weight: 285.7

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An adenosine deaminase inhibitor

MDL Number: MFCD00153939

PubChem CID: 20279

SMILES: C1C(C(OC1N2C=NC3=C2N=C(N=C3N)Cl)CO)O

InChi: InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1

InChi Key: PTOAARAWEBMLNO-KVQBGUIXSA-N