Cleaved-CASP4 p20 (Q81) Polyclonal Antibody | E-AB-30021

Cleaved-CASP4 p20 (Q81) Polyclonal Antibody | E-AB-30021 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Apoptotic cysteine protease Mih1/TX, CASP-4, CASP4, CASP4, Caspase 4 apoptosis related cysteine peptidase, Caspase-4 subunit 2, Caspase4, ICE(rel)-II, ICE(rel)II, ICEREL II, ICH2, Mih1/TX, Protease ICH-2, Protease TX, TX

Application: WB, IHC-p, ELISA

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cell Biology, Metabolism

Background: This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthesized peptide derived from the Internal region of human Caspase-4 p20

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 43 kDa

Molecular Weight(Observed): 43+22 kDa