Cleaved-KLK8 (V33) polyclonal Antibody | BS7042

Cleaved-KLK8 (V33) polyclonal Antibody | BS7042 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Kallikrein-8 (KLK8), also called neuropsin precursor, ovasin or serine protease 19, is a 260 amino acid secreted protein involved in hippocampal plasticity. Two isoforms exist for this protein. Isoform 1 is the primary form of KLK8 found predominantly in the pancreas. Isoform 2 contains an additional 46 amino acids after amino acid 23 and is predominantly expressed in adult brain and hippocampus. Isoform 2 is not common to the mouse homolog or other primate homologs. In humans, the T to A mutation (c.71-127T>A) leads to the splice variant seen in the human brain. Both isoforms are detected in fetal brain and placenta. In some cancer cells, KLK8 expression can suppress tumor cell invasiveness and lead to a favorable clinical outcome.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Cleaved-KLK8 (V33) polyclonal Antibody detects endogenous levels of Cleaved-KLK8 (24 kDa) protein and Pro-KLK8 (28 kDa) Protein.

Molecular Weight: ~ 24, 28 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Kallikrein-8; Hk8; Neuropsin; Ovasin; Serine protease 19; Serine protease TADG-14; Tumor-associated differentially expressed gene 14 protein; KLK8; NRPN; PRSS19; TADG14; UNQ283; PRO322; Kallikrein 8; Kallikrein8

Immunogen: Synthetic peptide, corresponding to amino acids 11-60 of Human KLK8.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A