CLEC1 Antibody | 33-024

CLEC1 Antibody | 33-024 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: A recombinant protein fragment from the N-terminal portin of human CLEC1 was used as the immunogen for this antibody.

Research Area: Immunology, Signal Transduction

Tested Application: WB

Application: Western blot: 2-5 ug/ml
Provided assay concentrations are suggestions only, CLEC1 antibody titration may be required for optimal results.

Specificiy: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: Protein A purified antibody

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide

Concentration: 0.5 mg/mL

Storage Condition: Aliquot and Store at -20˚C. Avoid freez-thaw cycles.

Alternate Name: N/A

User Note: Optimal dilutions for each application to be determined by the researcher

BACKGROUND: CLEC1 is a C-type lectin receptor and part of the ���Dectin-1 cluster��� subfamily which also includes Dectin-1, LOX-1, CLEC-2, MICL, CLEC12B, and CLEC9A. Similar to other family members, CLEC1 displays N-liked glycosylation and dimerization characteristics, and is found on dendritic cells, monocytes and granulocytes. However, unlike other family members, CLEC1 expression level is upregulated by IL-10 and TGFb, but not by pro-inflammatory stimuli, and it is expressed on endothelial cells. Enhanced expression at allograft sites suggests CLEC1 may have an immune-regulatory function and may support allograft tolerance.