CLEC4E Antibody | 33-011

CLEC4E Antibody | 33-011 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: A recombinant protein fragment from the C-terminal portion of human CLEC4E was used as the immunogen for this antibody.

Research Area: Immunology

Tested Application: WB

Application: Western blot: 2-5 ug/ml
Provided assay concentrations are suggestions only, CLEC4E antibody titration may be required for optimal results.

Specificiy: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: Protein A affinity chromatography

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide

Concentration: 0.5 mg/mL

Storage Condition: Aliquot and Store at -20˚C. Avoid freez-thaw cycles.

Alternate Name: N/A

User Note: Optimal dilutions for each application to be determined by the researcher

BACKGROUND: CLEC4 is a member of the C-type lectin family of proteins that plays a role in inflammatory and immune response. CLEC4E, also called Mincle (Macrophage-inducible C-type lectin) , is found on the surface of activated macrophages and phagocytes. It is a receptor for both non-self (fungi and mycobacteria) , and self (damaged cells) ligands. Dead cells release SAP130 (Sin3A-Associated Protein, 130kDa) , a small nuclear ribonucleoprotein component. CLEC4E senses this and interacts with the ITAM-containing adaptor protein FcRgamma, and via Syk and CARD9 signaling, activates the production of inflammatory cytokines such as TNFa, MIP-2 and IL-6.