CLEC6A polyclonal Antibody | BS60545

CLEC6A polyclonal Antibody | BS60545 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Together, Dectin-1 and Dectin-2 make up the unique subfamily of dendritic cell-associated C-type lectins. Dectin-2 is expressed on antigen-presenting cells, where it interacts with its putative ligands on T cells. That interaction may deliver co-stimulatory signals in naive T cells. Dectin-2 expression is upregulated during monocyte activation and maturation at inflammatory lesions. Broadband UV-B upregulates Dectin-2 expression in Langerhans cells by activating the Dectin-2 gene promoter, suggesting that this protein plays a crucial role in the mediation of UV-induced immunosuppression. In cattle, Dectin-2 expressed by dendritic cells may also play a role in the recognition of invading antigens in lymph nodes. Dectin-2 functions as a pattern recognition receptor for fungi that activates signaling through FcR© to induce innate immune responses.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CLEC6A polyclonal Antibody detects endogenous levels of CLEC6A protein.

Molecular Weight: ~ 24 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: C-type lectin domain family 6 member A; C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2; DC-associated C-type lectin 2; Dectin-2; CLEC6A; CLECSF10; DECTIN2

Immunogen: A synthetic peptide corresponding to residues in Human CLEC6A

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: