Clemastine Fumarate | B2525

Clemastine fumarate is a selective histamine H1 receptor antagonist (Ki = 0.26 nM); also displays high affinity for muscarinic receptors (Ki = 16 nM). Also acts as a positive allosteric modulator of P2X7 receptor signaling. Clinically-used as an antihistamine agent.

Clemastine fumarate is a selective histamine H1 receptor antagonist (Ki = 0.26 nM); also displays high affinity for muscarinic receptors (Ki = 16 nM). Also acts as a positive allosteric modulator of P2X7 receptor signaling. Clinically-used as an antihistamine agent.

B2525 | Clemastine Fumarate DataSheet

Alternate Name/Synonyms: (2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-pyrrolidine, 2E-butenedioate

Appearance: White solid

Formulation:

CAS Number: 14976-57-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₆ClNO.C₄H₄O₄

Molecular Weight: 459.97

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >20 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective histamine H1 receptor antagonist

MDL Number: MFCD00137486

PubChem CID: 5281069

SMILES: CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C.C(=CC(=O)O)C(=O)O

InChi: InChI=1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1

InChi Key: PMGQWSIVQFOFOQ-YKVZVUFRSA-N