CLIC5 Antibody [APG02658G]

CLIC5 Antibody [APG02658G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CLIC5 antibody is generated from rabbits immunized with human recombinant CLIC5 protein.

Cellular Localisation: [Isoform 1]: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Membrane; Single-pass membrane protein. Apical cell membrane; Single-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:O00299} Note=Associates with the cortical actin cytoskeleton (PubMed:10793131, PubMed:15184393) . Localizes to the apical region of cochlear hair cells, at the base of the actin-rich hair bundle (By similarity) Colocalizes with podocalyxin at the apical cell membrane in renal glomeruli (PubMed:20335315) . May localize to the centrosome in lens epithelial cells (By similarity) . Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity) . {ECO:0000250|UniProtKB:O00299, ECO:0000250|UniProtKB:Q8BXK9, ECO:0000250|UniProtKB:Q9EPT8, ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:15184393, ECO:0000269|PubMed:20335315}

Molecular Weight: 46503

Clone: Polyclonal

Gene Name: CLIC5

Gene ID: 53405

Function: Required for normal hearing (PubMed:24781754) . It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity) . Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed:15184393, PubMed:18028448, PubMed:20335315) . Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens (By similarity) .

Summary: Tissue Location: Widely expressed in both fetal and adult human tissues (PubMed:24781754) . Isoform 1 is expressed in renal glomeruli endothelial cells and podocytes (at protein level)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Chloride intracellular channel protein 5, CLIC5