Clioquinol | 2454

An antiparasitic agent that forms stable complexes with copper and used for treatment of Alzheimer’s disease. Displays anticancer properties by inhibition of proteasome activity. It targets tumor proteasome in vivo in a copper-dependent manner, resulting in formation of an active AR (androgen receptor) inhibitor and apoptosis inducer that is responsible for its observed antiprostate tumor effect.

Clioquinol is an antiparasitic agent that forms stable complexes with copper and used for treatment of Alzheimer’s disease. Displays anticancer properties by inhibition of proteasome activity.

2454 | Clioquinol DataSheet

Alternate Name/Synonyms: 5-Chloro-8-hydroxy-7-iodoquinoline, 5-chloro-7-iodo-8-quinolinol; CQ

Appearance: Tan solid

Formulation: N/A

CAS Number: 130-26-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₉H₅CIlNO

Molecular Weight: 305.5

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A proteasome inhibitor and an anticancer agent

MDL Number: MFCD00006787

PubChem CID: 2788

SMILES: C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1

InChi: InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H

InChi Key: QCDFBFJGMNKBDO-UHFFFAOYSA-N