CLIP-170 polyclonal Antibody | BS71882

CLIP-170 polyclonal Antibody | BS71882 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200

Background: Cytoplasmic linker protein of 170 kDa (CLIP-170) is the original member of a group of microtuble binding proteins designated as plus-end-binding proteins (+TIPs) . CLIP-170 binds to the growing plus ends of microtubules and acts as a linker between the dynamic microtubule ends and organelle membranes. The protein acts as an anticatastrophic factor, promoting microtubule rescue near the cell periphery. Fluorescently labeled CLIP-170 can be visualized as a comet like streak around the growing ends of microtubules. CLIP-170 colocalizes with dynactin and dynein at microtubule ends and also at the kinetochore. Restin, first identified as a marker for Hodgkin and Reed-Sternberg (HRS) cells, is a 160 kDa splice variant of the gene that includes a 35 amino acid stretch not present in CLIP-170.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CLIP-170 polyclonal Antibody detects endogenous levels of CLIP-170 protein.

Molecular Weight: 162kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CAP-Gly domain-containing linker protein 1; Cytoplasmic linker protein 1; Cytoplasmic linker protein 170 alpha-2; CLIP170; Reed-Sternberg intermediate filament-associated protein; Restin; CLIP1; CYLN1; RSN

Immunogen: Recombinant protein of human CLIP1

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: