Clofarabine | 2236

A purine nucleoside antimetabolite that displays anticancer activity. Clofarabine displays potent inhibitory effects on both ribonucleotide reductase and DNA polymerase. Used in pediatrics to treat a type of blood cancer called acute lymphoblastic leukemia (ALL).

A purine nucleoside antimetabolite that displays anticancer activity. Clofarabine displays potent inhibitory effects on both ribonucleotide reductase and DNA polymerase

2236 | Clofarabine DataSheet

Alternate Name/Synonyms: (2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

Appearance: Off-white solid

Formulation: N/A

CAS Number: 123318-82-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₀H₁₁ClFN₅O₃

Molecular Weight: 303.68

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: DMSO

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A purine nucleoside antimetabolite

MDL Number: MFCD00871077

PubChem CID: 119182

SMILES: C1=NC2=C(N1C3C(C(C(O3)CO)O)F)N=C(N=C2N)Cl

InChi: InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1

InChi Key: WDDPHFBMKLOVOX-AYQXTPAHSA-N