CM-272 | B3250

CM-272 is a potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor. CM-272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC50s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM-272 inhibits cell proliferation and promotes apoptosis, inducing IFN-stimulated genes and immunogenic cell death. Displays anti-tumor activity.

CM-272 is a potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor. CM-272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC50s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM-272 inhibits cell proliferation and promotes apoptosis, inducing IFN-stimulated genes and immunogenic cell death. Displays anti-tumor activity.

B3250 | CM-272 DataSheet

Alternate Name/Synonyms: [6-Methoxy-2-(5-methyl-furan-2-yl)-7-(3-pyrrolidin-1-yl-propoxy)-quinolin-4-yl]-(1-methyl-piperidin-4-yl)-amine CM272

Appearance: Crystalline solid

Formulation:

CAS Number: 1846570-31-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₃₈N₄O₃

Molecular Weight: 478.64

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A dual G9a/DNA methyltransferases (DNMTs) inhibitor

MDL Number:

PubChem CID: 118607432

SMILES: CN1CCC(NC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1

InChi: InChI=1S/C28H38N4O3/c1-20-7-8-26(35-20)25-18-23(29-21-9-14-31(2)15-10-21)22-17-27(33-3)28(19-24(22)30-25)34-16-6-13-32-11-4-5-12-32/h7-8,17-19,21H,4-6,9-16H2,1-3H3,(H,29,30)

InChi Key: RLQLKZTYUYIWDB-UHFFFAOYSA-N