CMIP Antibody (C-term) [APR04537G]

CMIP Antibody (C-term) [APR04537G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CMIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 735-764 amino acids from the C-terminal region of human CMIP.

Cellular Localisation: Nucleus. Cytoplasm. Note=Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS) (PubMed:12939343) (PubMed:15616553) . Detected in nuclear and cytoplasmic compartments during MCNS relapse (PubMed:12939343) (PubMed:15616553) . Expressed in cytoplasm only during MCNS remission and absent in normal patients (PubMed:12939343)

Molecular Weight: 86331

Clone: Polyclonal

Gene Name: CMIP

Gene ID: 80790

Function: Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.

Summary: Tissue Location: Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: C-Maf-inducing protein, c-Mip, Truncated c-Maf-inducing protein, Tc-Mip, CMIP, KIAA1694, TCMIP