CMPD-1 | B2991

MK2a inhibitor is a substrate-selective inhibitor of p38α MAPK that selectively inhibits p38α-dependent phosphorylation of mitogen-activated protein kinase-activated protein kinase 2 (MK2a) with a K(i)(app) of 330 nM. It does not inhibit the phosphorylation of ATF-2 and MBP. It inhibits proliferation of U87, A172, and U251 glioblastoma cells with EC₅₀ values of 0.6-1 μM by inhibition of tubulin polymerization and induction of apoptosis.

MK2a inhibitor is a substrate-selective inhibitor of p38α MAPK that selectively inhibits p38α-dependent phosphorylation of mitogen-activated protein kinase-activated protein kinase 2 (MK2a) with a K(i)(app) of 330 nM. It does not inhibit the phosphorylation of ATF-2 and MBP. It inhibits proliferation of U87, A172, and U251 glioblastoma cells with EC₅₀ values of 0.6-1 μM by inhibition of tubulin polymerization and induction of apoptosis.

B2991 | CMPD-1 DataSheet

Alternate Name/Synonyms: 4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide; 2'-fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide; Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor; MK2a Inhibitor

Appearance: Pale pink solid

Formulation:

CAS Number: 41179-33-3

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₂₂H₂₀FN₀O₂

Molecular Weight: 349.4

Cell-Permeable?: True

Purity: ≥99%

Solubilities: ~35 mg/ml in DMSO and Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of p38α-mediated MK2a phosphorylation

MDL Number: MFCD08703098

PubChem CID: 11382492

SMILES: C1=CC=C(C(=C1)C2=CC=C(C=C2)CCCC(=O)NC3=CC=C(C=C3)O)F

InChi: InChI=1S/C22H20FNO2/c23-21-6-2-1-5-20(21)17-10-8-16(9-11-17)4-3-7-22(26)24-18-12-14-19(25)15-13-18/h1-2,5-6,8-15,25H,3-4,7H2,(H,24,26)

InChi Key: ODYAQBDIXCVKAE-UHFFFAOYSA-N