CMPD101 | B3392

CMPD101 | B3392

Description: CMPD101 is a potent, selective and cell-permeable GRK2/3 inhibitor (IC50 values are 32 and 54 nM for GRK3 and GRK2, respectively). CMPD101 displays selectivity for GRK2/3 over GRK1/5. CMPD101 displays less selectively against GRK1, GRK5, ROCK-2 and PKCα with IC50s of 3.1 μM, 2.3 μM, 1.4 μM and 8.1 μM, respectively.

Alternate Name/Synonyms: 3-[[[4-Methyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]methyl]amino]-N-[[2-(trifluoromethyl)phenyl]methyl]benzamide

Appearance: Off-white solid

Formulation:

CAS Number: 865608-11-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₁F₃N₆O

Molecular Weight: 466.46

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >40 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling contact by all modes of exposure.

Tag Line: A potent and selective GRK2/3 inhibitor

MDL Number:

PubChem CID: 11677079

PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/11677079

SMILES: CN1C(=NN=C1C2=CC=NC=C2)CNC3=CC=CC(=C3)C(=O)NCC4=CC=CC=C4C(F)(F)F

InChi: InChI=1S/C24H21F3N6O/c1-33-21(31-32-22(33)16-9-11-28-12-10-16)15-29-19-7-4-6-17(13-19)23(34)30-14-18-5-2-3-8-20(18)24(25,26)27/h2-13,29H,14-15H2,1H3,(H,30,34)

InChi Key: WFOVEDJTASPCIR-UHFFFAOYSA-N

Category: Biochemicals