CNDP2 Antibody (C-term) [APR04176G]

CNDP2 Antibody (C-term) [APR04176G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CNDP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 348-375 amino acids from the C-terminal region of human CNDP2.

Cellular Localisation: Cytoplasm

Molecular Weight: 52878

Clone: Polyclonal

Gene Name: CNDP2 {ECO:0000303|PubMed:25964343, ECO:0000312|HGNC:HGNC:24437}

Gene ID: 55748

Function: Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides (By similarity) . Mediates threonyl dipeptide catabolism in a tissue- specific way (By similarity) . Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism (PubMed:19346245, PubMed:12473676) . Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis (PubMed:25964343) . Plays a role in the regulation of cell cycle arrest and apoptosis (PubMed:17121880, PubMed:24395568) .

Summary: Tissue Location: [Isoform 1]: Ubiquitously expressed with higher levels in kidney and liver (at protein level) . Expressed in peripheral blood leukocytes (PubMed:12473676) . Expressed in gastric mucosa and down-regulated in gastric cancer mucosal tissues (at protein level) (PubMed:24395568) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Cytosolic non-specific dipeptidase, CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2, CN2, CPGL, PEPA