CNR2 Antibody (N-term) [APR33024G]

CNR2 Antibody (N-term) [APR33024G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CNR2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 18-53 amino acids from the N-terminal region of human CNR2.

Cellular Localisation: Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon Note=Localizes to apical dendrite of pyramidal neurons.

Molecular Weight: 39681

Clone: Polyclonal

Gene Name: CNR2

Gene ID: 1269

Function: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

Summary: Tissue Location: Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level) . Expressed in skin in suprabasal layers and hair follicles (at protein level) . Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level) . Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Cannabinoid receptor 2, CB-2, CB2, hCB2, CX5, CNR2, CB2A, CB2B