CNTN1 Antibody (Center) [APR11618G]

CNTN1 Antibody (Center) [APR11618G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CNTN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 635-662 amino acids from the Central region of human CNTN1.

Cellular Localisation: [Isoform 1]: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side

Molecular Weight: 113320

Clone: Polyclonal

Gene Name: CNTN1

Gene ID: 1272

Function: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity) .

Summary: Tissue Location: Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Contactin-1, Glycoprotein gp135, Neural cell surface protein F3, CNTN1