CO-1686 (Rociletinib) | 2794

CO-1686 is an orally bioavailable, irreversible EGFR inhibitor, selectively targeting EGFRL858R/T790M mutant with a Ki value of 21 nM over Wt EGFR (Ki = 303 nM). Displays potent antineoplastic activities.

CO-1686 is an orally bioavailable, irreversible EGFR inhibitor, selectively targeting EGFRL858R/T790M mutant with a Ki value of 21 nM over Wt EGFR (Ki = 303 nM). Displays potent antineoplastic activities.

2794 | CO-1686 (Rociletinib) DataSheet

Alternate Name/Synonyms: N-(3-((2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide; AVL-301

Appearance: White solid

Formulation: N/A

CAS Number: 1374640-70-6

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₈F₃N₇O₃

Molecular Weight: 555.55

Cell-Permeable?: y

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent EGFR inhibitor

MDL Number: N/A

PubChem CID: 57335384

SMILES: CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC

InChi: InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)

InChi Key: HUFOZJXAKZVRNJ-UHFFFAOYSA-N