CO4c | Complement component C4c | IMS01-031-305

CO4c | Complement component C4c | IMS01-031-305 | Gentaur UK, US & Europe Distribution

Immunogen: full lenth native CO4c | Complement component C4c protein purified from human plasma

Host: Chicken

Conjugation: N/A

Clonality: Polyclonal

Isotype: N/A

Purity: Purified, total IgY (chicken egg yolk immunoglobulin) in 0.9% NaCl, 0.02% sodium azide.

Format: Liquid

Tested Application: Total, purified IgY

Related Products: IMS02-032-303 | Anti-Complement component C4, chicken antibodiesIMS06-032-304 | Anti-Complement component C4, biotinylated, chicken antibodiesIMS01-066-309 | Anti-Complement factor H, chicken antibodiesSecondary antibodies

Recommended Dilutions: Use at an assay dependent dilution (WB)

Molecular weight: 35 kDa

Confirmed Reactivity: Human

Predicted Reactivity: Human

Not reactive in: No confirmed exceptions from predicted reactivity are currently known

Additional Information: Only one precipitin arcs in immunodiffusion against normal human serum or human C4. Reacts with α and β chain in electroblotting.The names C4 and C4c for this target protein are frequently used together and almost interchangeably. The difference between the two is a single cleavage and the difference will not be able to be discerned in a polyclonal antibody.

Background: Complement component C4 consists of three polypeptide chains (alpha, molecular weight 95 kDa; beta, molecular weight 75 kDa and gamma, molecular weight 33 kDa) and is usually present in serum at 200-600 mg/L. It is a protein of the classical complement pathway. When activated by C1s, peptide C4a is released and the generated C4b binds C2 which is in turn cleaved by C1s to produce the classical pathway C3 convertase, namely C4b2a. C4b also has opsonin activity and binds to macrophages and neutrophils via their CR1 receptor.

Reconstitution: N/A

Storage: Store at 4°C; make aliquots to avoid working with a stock. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

TAIR Nnumbre: N/A

Category: Immunology

Research Area: Immunology