COASY Antibody | 14-298

COASY Antibody | 14-298 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 345-564 of human COASY (NP_079509.5) .

Research Area: Cancer, Signal Transduction

Tested Application: WB, IHC

Application: WB: 1:500 - 1:2000
IHC: 1:100 - 1:200

Specificiy: N/A

Positive Control 1: LO2

Positive Control 2: 293T

Positive Control 3: A-549

Positive Control 4: SKOV3

Positive Control 5: Mouse heart

Positive Control 6: Mouse liver

Molecular Weight: Observed: 62kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: DPCK, NBIA6, NBP, PCH12, PPAT, UKR1, pOV-2, bifunctional coenzyme A synthase, CoA synthase, bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase, nucleotide binding protein, phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5) . The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA) . Alternative splicing results in multiple isoforms.