Cobicistat | 9474

Cobicistat (GS-9350) is a potent, and selective inhibitor of human cytochrome P450 3A (CYP3A) enzymes (Ki = 939 nM). Acts as a pharmacoenhancing or "boosting" agent for antiviral drugs used in the treatment of HIV infection.

Cobicistat (GS-9350) is a potent, and selective inhibitor of human cytochrome P450 3A (CYP3A) enzymes (Ki = 939 nM). Acts as a pharmacoenhancing or "boosting" agent for antiviral drugs used in the treatment of HIV infection.

9474 | Cobicistat DataSheet

Alternate Name/Synonyms: 1,3-thiazol-5-ylmethyl N-[(2R,5R)-5-[[(2S)-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-4-morpholin-4-ylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate; GS-9350

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1004316-88-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₄₀H₅₃N₇O₅S₂

Molecular Weight: 776.02

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~8 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, and selective inhibitor of human cytochrome P450 3A (CYP3A) enzymes

MDL Number: N/A

PubChem CID: 25151504

SMILES: CC(C)C1=NC(=CS1)CN(C)C(=O)NC(CCN2CCOCC2)C(=O)NC(CCC(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5

InChi: InChI=1S/C40H53N7O5S2/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49)/t32-,33-,36+/m1/s1

InChi Key: ZCIGNRJZKPOIKD-CQXVEOKZSA-N