COCO/DAND5 Antibody | 3626

COCO, also known as DAND5, Dante, and CKTSF1B3, is a member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus? DAND3), and Cerberus (DAND4). DAN family members contain a cysteine knot domain that is homologous to that found in other TGF­? superfamily ligands such as BMPs that play important roles in tissue morphogenesis and developmental processes. COCO has eight Cys residues in the cysteine knot which places it in the CAN (or eight­membered ring) subfamily of BMP antagonists along with the other DAN family proteins. In Xenopus embryos, COCO is expressed by pluripotent ectodermal cells. Expression is abruptly downregulated prior to gastrulation, and the loss of ectodermal cell pluripotency is coincident with COCO downregulation. COCO is required for Xenopus left­right axis formation. It functions predominantly on the right side of the embryo, although it is equally expressed on both left and right sides. COCO binds and inhibits activin, BMP­4, GDF3/derrière, Wnt8, and Xnr1. In mouse, COCO expression is elevated on the right side of Henson’s node at the early somite stage, in contrast to the left side expression of Nodal.

3626 | COCO/DAND5 Antibody DataSheet

Antibody Target: COCO/DAND5

Target Alternative Name: DANTE, CKTSF1B3, DAN domain family member 5, Cerberus-like 2 protein

Tag Line: Polyclonal antibody to detect COCO/DAND5 in human mouse and rat samples

Category: COCO/DAND5

Host: Rabbit

Isotype: Rabbit IgG

Species Reactivities: Human, mouse, rat

Immunogen Sequence: Synthetic peptide at C-terminal (BV-MM26)

Accession #: Q8N907

Gene ID: 199699

Appearance: Colourless liquid

Form: Liquid

Concentration: 0.5 mg/ml

Formulation: 100 µg (0.5 mg/ml) of antibody in PBS containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2.

Purification: Affinity purified

Application: Western blot

Positive Control: Jurkat cell lysate

Application And Usages: Western blot: 1:200

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: Verified

Immunocytochemistry Verified: Not Verified

Immunofluorescence Verified: Not Verified

Immunoprecipitation Verified: Not Verified

FACS Verified: Not Verified

ELISA Verified: Not Verified

ChIP Verified: Not Verified

Dot Blot Verified:

Flow Cytometry Verified: Not Verified