Cofilin1/2 (T88) polyclonal Antibody | BS2183

Cofilin1/2 (T88) polyclonal Antibody | BS2183 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IF

Application Range: WB: 1:500~1:1000 IF: 1:50~1:200

Background: Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin,thereby regulating the rapid cycling of Actin assembly and disassembly essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous F-Actin by bridging two longitudinally associated Actin subunits changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser 3 by factors such as opsonized zymosan.Lim kinase 1, a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerise F-Actin.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Cofilin1/2 (T88) polyclonal Antibody detects endogenous levels of Cofilin1/2 protein.

Molecular Weight: ~ 19 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cofilin-1; Cofilin1; Cofilin 1; 18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform; CFL1; CFL; Cofilin-2; Cofilin2; Cofilin 2; Cofilin, muscle isoform; CFL2

Immunogen: Synthetic peptide, corresponding to amino acids 55-100 of Human Cofilin1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: