COG133 | B2969

COG 133 is a fragment of Apolipoprotein E (APOE) that mimics the anti-inflammatory and neuroprotective effects of the intact apoE protein. It functions through the low-density lipoprotein receptor-related protein (LRP). It reduces the symptoms of experimental autoimmune encephalomyelitis model of human multiple sclerosis, suppresses inflammation, demyelination and infiltration of cells into the spinal cord. It also acts as a non-competitive antagonist at α7 nicotinic acetylcholine receptors with an IC₅₀ of 445 nM.

COG 133 is a fragment of Apolipoprotein E (APOE) that mimics the anti-inflammatory and neuroprotective effects of the intact apoE protein. It functions through the low-density lipoprotein receptor-related protein (LRP). It reduces the symptoms of experimental autoimmune encephalomyelitis model of human multiple sclerosis, suppresses inflammation, demyelination and infiltration of cells into the spinal cord. It also acts as a non-competitive antagonist at α7 nicotinic acetylcholine receptors with an IC₅₀ of 445 nM.

B2969 | COG133 DataSheet

Alternate Name/Synonyms: apoE(133-149)

Appearance: Solid

Formulation:

CAS Number: 514200-66-9

Structure Available?: True

Peptide sequence: Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH₂

Salt Form: false

Molecular Formula: C₉₇H₁₈₁N₃₇O₁₉

Molecular Weight: 2169.73

Cell-Permeable?: False

Purity: 99%

Solubilities: ~1 mg/ml in in Water, ~217 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An ApoE mimetic peptide

MDL Number:

PubChem CID: 90488841

SMILES: CC(C)CC(C(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CC1=CNC=N1)NC(=O)C(CO)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C

InChi: InChI=1S/C97H181N37O19/c1-50(2)40-67(76(100)137)127-89(150)72(45-55(11)12)130-82(143)64(30-23-37-114-95(105)106)122-78(139)60(26-17-19-33-98)120-79(140)62(28-21-35-112-93(101)102)123-87(148)70(43-53(7)8)129-81(142)61(27-18-20-34-99)121-80(141)63(29-22-36-113-94(103)104)124-88(149)71(44-54(9)10)131-90(151)73(46-59-47-111-49-117-59)132-91(152)74(48-135)133-77(138)57(15)118-85(146)69(42-52(5)6)128-83(144)65(31-24-38-115-96(107)108)126-92(153)75(56(13)14)134-84(145)66(32-25-39-116-97(109)110)125-86(147)68(41-51(3)4)119-58(16)136/h47,49-57,60-75,135H,17-46,48,98-99H2,1-16H3,(H2,100,137)(H,111,117)(H,118,146)(H,119,136)(H,120,140)(H,121,141)(H,122,139)(H,123,148)(H,124,149)(H,125,147)(H,126,153)(H,127,150)(H,128,144)(H,129,142)(H,130,143)(H,131,151)(H,132,152)(H,133,138)(H,134,145)(H4,101,102,112)(H4,103,104,113)(H4,105,106,114)(H4,107,108,115)(H4,109,110,116)/t57-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-/m0/s1

InChi Key: QTWXJKVJIKDSLC-KIZXDXQLSA-N