COL11A1 (G610) polyclonal Antibody | BS2182

COL11A1 (G610) polyclonal Antibody | BS2182 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: IHC

Application Range: IHC: 1:50~1:200

Background: Collagen Type XI is an 1806 amino acid protein belonging to the fibrillar collagen family. Collagen Type XI is thought to play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. This protein forms trimers composed of three different chains: a 1 (XI), a 2 (XI), and a 3 (XI) . a 3 (XI) is a post-translational modification of a 1 (II) . a 1 (V) can also be found instead of a 3 (XI) . Collagen Type XI has three named isoforms (A,B,C) and additional isoforms seem to exist, stemming from alternative usage of exon IIA or exon IIB. Transcripts containing exon IIA or IIB are present in cartilage, but exon IIB is preferentially utilized in transcripts from tendon. Collagen Type XI contains a single collagen binding TSP N-terminal (TSPN) domain. Collagen Type XI is expressed in cartilage, placenta and some tumor or virally transformed cell lines. Isoform expression can be tissue specific. Defects in the COL11A gene are the cause of Stickler syndrome type 2 (STL2), or beaded vitreous type, due to the presence of irregularly thickened fiber bundles throughout vitreous cavity.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: COL11A1 (G610) polyclonal Antibody detects endogenous levels of COL11A1 protein.

Molecular Weight: ~181 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: COBA1; COL11A1; COLL6; Collagen alpha 1; Collagen alpha-1 (XI) chain; collagen XI alpha 1; collagen XI; alpha 1 polypeptide; collagen; type XI; alpha 1; STL2; STL3; XI chain precursor;

Immunogen: Synthetic peptide, corresponding to amino acids 571-620 of Human COL11A1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Phosphoinosotode Signaling,Regulation of Actin Dynamics,Tumor Angiogenesis,Regulation of Microtubule Dynamics,