COL17A1 Polyclonal Antibody | E-AB-17809

COL17A1 Polyclonal Antibody | E-AB-17809 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: 180 kDa bullous pemphigoid antigen 2, Alpha 1 type XVII collagen, BA16H23.2, BP 180, BP180, BPA 2, BPAG 2, BPAG2, Bullous pemphigoid antigen 2, COL17A1, Collagen 17, Collagen alpha 1 XVII chain, Collagen alpha 1(XVII) chain, Collagen alpha1 XVII chain, Collagen type XVII alpha 1, Collagen XVII alpha 1 polypeptide, CollagenXVII, Epidermolysis bullosa junctional localisata variant, FLJ60881, KIAA0204, LAD 1, LAD1

Application: IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Signal Transduction

Background: COL17A1 (Collagen Type XVII Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL17A1 include Epidermolysis Bullosa, Junctional, Non-Herlitz Type and Epithelial Recurrent Erosion Dystrophy. Among its related pathways are Collagen chain trimerization and Phospholipase-C Pathway. An important paralog of this gene is COL6A1.This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form.

Concentration: 0.6 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human COL17A1

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: IHC 1:50-1:200, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A