Combretastatin A4 | 2239

A vascular disrupting, antineoplastic and microtubule-depolymerizing agent. Binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, it disrupts the engagement of the endothelial cell–specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and thus the activity of the VE-cadherin/β-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation.

A vascular disrupting, antineoplastic and microtubule-depolymerizing agent.

2239 | Combretastatin A4 DataSheet

Alternate Name/Synonyms: 2-Methoxy-5-[(1Z)-2-(3,4,5-trimetho-xyphenyl)ethenyl]phenol; CRC 87-09, NSC 817373

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 117048-59-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₀O₅

Molecular Weight: 316.35

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mM) or EtOH (100 mM)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A vascular disrupting, antineoplastic and microtubule-depolymerizing agent.

MDL Number: MFCD03453309

PubChem CID: 5351344

SMILES: COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)O

InChi: InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-

InChi Key: HVXBOLULGPECHP-WAYWQWQTSA-N