COMMD1 Antibody (N-Term) [APR33414G]

COMMD1 Antibody (N-Term) [APR33414G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This COMMD1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 4--33 amino acids from human COMMD1.

Cellular Localisation: Nucleus. Cytoplasm Endosome membrane. Cytoplasmic vesicle. Early endosome. Recycling endosome Note=Shuttles between nucleus and cytosol. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins

Molecular Weight: 21178

Clone: Polyclonal

Gene Name: COMMD1

Gene ID: 150684

Function: Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237) . Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074) . Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529) . Modulates Na (+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370) . Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:21483833) . Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:20595380) . Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947) . Can bind one copper ion per monomer (PubMed:17309234) . May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4, 5- bisphosphate (PtdIns (4, 5) P2) (PubMed:18940794) . Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1- beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:20458141) . Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin- dependent manner (PubMed:28604741) .

Summary: Tissue Location: Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta. Down-regulated in cancer tissues.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: COMM domain-containing protein 1, Protein Murr1, COMMD1, C2orf5, MURR1