Complement C5, Human Plasma | P1273

Complement Component 5 (C5) plays a central role in inflammatory and cellular death processes. This protein is composed of alpha and beta polypeptide chains that are linked by a disulfide bridge. The protein gets cleaved into C5a and C5b which are subsequently responsible for chemotaxis, inflammation, and initiating the formation of the membrane attack complex (MAC). Drugs that inhibit complement C5 have been used in Paroxysmal nocturnal hemoglobinuria (PNH) patients to lessen thrombotic complications by lessening intravascular hemolysis.

P1273 | Complement C5 Human Plasma DataSheet

Biomolecule/Target: C5

Synonyms: Compelement C5

Alternates names: bone morphogenetic protein 11, BMP11, BMP 11, Growth/Differentiation Factor-11, GDF-11, GDF11, GDF 11

Taglines: A potent chemotactic factor for human peripheral blood neutrophils and monocytes

NCBI Gene ID #: 10220

NCBI Gene Symbol: BMP11/GDF11

Gene Source: Human

Accession #: O95390

Recombinant: No

Source: Human Plasma

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: The protein is biologically active as determined by its ability to induce alkaline phosphatase production by C2C12 cells. The ED is in the range of 0.4-4 µg/ml.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 32.6 kDa

Concentration: N/A

Appearance: Liquid

Physical form description: In PBS, pH 7.4

Reconstitution Instructions: Reconstitute to a concentration of 0.1-1.0 mg/ml in HO containing BSA (50 g BSA per 1 g of protein). This solution can then be diluted into other aqueous buffers.

Amino acid sequence: N/A