Compound 401 | 1657

Cell-permeable. A reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) (IC₅₀ = 0.28 µM) that also targets mTOR (IC₅₀ = 5. 3µM), but not PI 3-K in vitro. Induces apoptosis in vitro.

Compound 401 is a cell-permeable, and reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) (IC₅₀ = 0.28 µM) that also targets mTOR (IC₅₀ = 5. 3µM), but not PI 3-K in vitro. Induces apoptosis in vitro.

1657 | Compound 401 DataSheet

Alternate Name/Synonyms: 2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 168425-64-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₅N₃O₂

Molecular Weight: 281.31

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO (10 mM) or EtOH (5 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A DNA-PK inhibitor

MDL Number: MFCD10568147

PubChem CID: 10039361

SMILES: C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2

InChi: InChI=1S/C16H15N3O2/c20-15-11-14(18-7-9-21-10-8-18)17-16-13-4-2-1-3-12(13)5-6-19(15)16/h1-6,11H,7-10H2

InChi Key: BVRDQVRQVGRNHG-UHFFFAOYSA-N