COMT polyclonal Antibody | BS7956

COMT polyclonal Antibody | BS7956 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IP

Application Range: WB 1:500 - 1:2000 IP 1:50 - 1:100

Background: Catechol-O-methyltransferase (COMT) plays a crucial role in the regulation of central dopaminergic systems by catalyzing the inactivation of catechol-amines. It is widely distributed in most tissues in soluble and membrane-bound forms. COMT-mediated methylation metabolism of catecholamine neurotransmitters is a first-line detoxification pathway. A Val158Met polymorphism of the COMT gene affects activity of the enzyme and influences performance and efficiency of the prefrontal cortex of the brain. Sequential conversion of estradiol to methoxyestradiol by COMT, contributes to the antimitogenic effects of estradiol on vascular smooth muscle cell growth via estrogen receptor-independent mechanisms. COMTD1 (catechol O-methyltransferase domain-containing protein 1) is a 262 amino acid single-pass type II membrane protein that belongs to the methyltransferase superfamily.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: COMT polyclonal Antibody detects endogenous levels of COMT protein.

Molecular Weight: ~ 25, 30 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Catechol O methyltransferase; COMT

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 42-221 of human COMT (NP_009294.1) .

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A