COMT polyclonal Antibody | BS90320

COMT polyclonal Antibody | BS90320 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC

Application Range: WB:1:500-1:2,000 IHC:1:50-1:100

Background: Catechol-O-methyltransferase (COMT) plays a crucial role in the regulation of central dopaminergic systems by catalyzing the inactivation of catechol-amines. It is widely distributed in most tissues in soluble and membrane-bound forms. COMT-mediated methylation metabolism of catecholamine neurotransmitters is a first-line detoxification pathway. A Val158Met polymorphism of the COMT gene affects activity of the enzyme and influences performance and efficiency of the prefrontal cortex of the brain. Sequential conversion of estradiol to methoxyestradiol by COMT, contributes to the antimitogenic effects of estradiol on vascular smooth muscle cell growth via estrogen receptor-independent mechanisms.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: COMT polyclonal Antibody detects endogenous levels of COMT protein.

Molecular Weight: 24 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: COMT, Catechol O methyltransferase, Catechol O-methyltransferase, COMT, COMT, EC 2.1.1.6,

Immunogen: Recombinant protein of C-terminal human COMT.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: