Conduritol B Epoxide | 9574

Conduritol B epoxide (CBE) is an irreversible inhibitor of glucocerebrosidase, also known as acid β-glucosidase, glucosylceramidase, GBA, or GBA1 (IC₅₀ = 9 μM). Inhibition of this lysosomal glucosidase results in the accumulation of glucocerebroside without affecting cell viability, lysosomal enzyme release, or the activity of intracellular enzymes. It also does not inhibit non-lysosomal glucosylceramidase or cytosolic β-glucosidase.

Conduritol B epoxide (CBE) is an irreversible inhibitor of glucocerebrosidase, also known as acid β-glucosidase, glucosylceramidase, GBA, or GBA1 (IC₅₀ = 9 μM). Inhibition of this lysosomal glucosidase results in the accumulation of glucocerebroside without affecting cell viability, lysosomal enzyme release, or the activity of intracellular enzymes. It also does not inhibit non-lysosomal glucosylceramidase or cytosolic β-glucosidase.

9574 | Conduritol B Epoxide DataSheet

Alternate Name/Synonyms: D,L-1,2-Anhydro-myo-inositol; CBE

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 6090-95-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₆H₁₀O₅

Molecular Weight: 162.14

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO ~25 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An irreversible inhibitor of glucocerebrosidase

MDL Number: MFCD00077326

PubChem CID: 119054

SMILES: C1(C(C(C2C(C1O)O2)O)O)O

InChi: InChI=1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H/t1-,2-,3+,4+,5-,6+/m0/s1

InChi Key: ZHMWOVGZCINIHW-FTYOSCRSSA-N