Conessine | B2772

Conessine is a plant steroid alkaloid that acts as a potent and specific antagonist of histamine H3 receptors. Conessine is 1860-fold selective for H3 over H4 and does not bind to H1 or H2 receptors. It also binds to the human α2C4 adrenergic receptor (pKi = 7.98).

Conessine is a plant steroid alkaloid that acts as a potent and specific antagonist of histamine H3 receptors. Conessine is 1860-fold selective for H3 over H4 and does not bind to H1 or H2 receptors. It also binds to the human α2C4 adrenergic receptor (pKi = 7.98).

B2772 | Conessine DataSheet

Alternate Name/Synonyms: Neriine,(3β)-N,N-dimethyl-con-5-enin-3-amine,Roquessine,NSC 119994

Appearance: White to off-white solid

Formulation:

CAS Number: 546-06-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₄₀N₂

Molecular Weight: 356.59

Cell-Permeable?: TRUE

Purity: ≥97%

Solubilities: >10 mg/ml DMSO, >10 mg/ml Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A specific antagonist of histamine H3 receptors

MDL Number: MFCD00016752

PubChem CID: 441082

SMILES: CC1C2CCC3C2(CCC4C3CC=C5C4(CCC(C5)N(C)C)C)CN1C

InChi: InChI=1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1

InChi Key: GPLGAQQQNWMVMM-MYAJQUOBSA-N