Conophylline | B3383

Conophylline | B3383

Description: Conophylline is a naturally occurring plant-based vinca alkaloid that acts as a novel differentiation inducer for pancreatic β cells; can increase the numbers of ductal cells positive for pancreatic-duodenal-homeobox protein-1 and islet-like cell clusters. Conophylline suppresses pancreatic stellate cells and improves islet fibrosis in Goto-Kakizaki rats. It protects cells in cellular models of neurodegenerative diseases by inducing mTOR-independent autophagy.

Alternate Name/Synonyms: dimethyl (14S,25S)-14,25-diethyl-24,33-dihydroxy-31,32-dimethoxy-12,22-dioxa-1,9,18,29-tetrazadodecacyclo[23.13.1.16,9.02,23.03,21.05,19.06,17.011,13.028,36.030,35.036,39.014,40]tetraconta-3,5(19),16,20,27,30,32,34-octaene-16,27-dicarboxylate CS-0023949

Appearance: Solid

Formulation:

CAS Number: 142741-24-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

C₄₄H₅₀N₄O₁₀

Molecular Weight: 794.9

Cell-Permeable?: True

Purity: ≥98%

Solubilities: DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Tag Line: A biologically active natural product

MDL Number:

PubChem CID: 9853848

PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/9853848

SMILES: CCC12CC(=C3C4(C1N(CC4)C5C(C2O)OC6=CC7=C(C=C56)C89CCN1C8C(CC(=C9N7)C(=O)OC)(C2C(C1)O2)CC)C1=CC(=C(C(=C1N3)OC)OC)O)C(=O)OC

InChi: InChI=1S/C44H50N4O10/c1-7-41-16-20(37(51)55-5)34-44(23-14-25(49)30(53-3)31(54-4)28(23)46-34)10-12-48(40(41)44)29-19-13-22-24(15-26(19)57-32(29)35(41)50)45-33-21(38(52)56-6)17-42(8-2)36-27(58-36)18-47-11-9-43(22,33)39(42)47/h13-15,27,29,32,35-36,39-40,45-46,49-50H,7-12,16-18H2,1-6H3

InChi Key: QZRIMAMDGWAHPQ-UHFFFAOYSA-N

Category: Biochemicals