Coumermycin A1 | B2414

Coumermycin A1 is a member of the aminocoumarin family of antibiotics that displays antibacterial activity against staphylococci and other gram-positive bacteria and some select gram-negative bacteria. Coumermycin A1 targets the B subunit of the bacterial DNA gyrase, inhibiting DNA synthesis.

Coumermycin A1 is a member of the aminocoumarin family of antibiotics that displays antibacterial activity against staphylococci and other gram-positive bacteria and some select gram-negative bacteria. Coumermycin A1 targets the B subunit of the bacterial DNA gyrase, inhibiting DNA synthesis.

B2414 | Coumermycin A1 DataSheet

Alternate Name/Synonyms: [(3~{R},4~{S},5~{R},6~{R})-5-hydroxy-6-[4-hydroxy-3-[[5-[[4-hydroxy-7-[(2~{R},3~{R},4~{S},5~{R})-3-hydroxy-5-methoxy-6,6-dimethyl-4-(5-methyl-1~{H}-pyrrole-2-carbonyl)oxyoxan-2-yl]oxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-4-methyl-1~{H}-pyrrole-3-carbonyl]amino]-8-methyl-2-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] 5-methyl-1~{H}-pyrrole-2-carboxylate, Sugordomycin D-1a, COUMERMYCIN

Appearance: White to off-white solid

Formulation:

CAS Number: 4434-05-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₅₅H₅₉N₅O₂₀

Molecular Weight: 1110.08

Cell-Permeable?: True

Purity: ≥98% by TLC

Solubilities: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A DNA gyrase inhibitor

MDL Number: MFCD00057312

PubChem CID: 54675768

SMILES: CC1=CC=C(N1)C(=O)OC2C(C(OC(C2OC)(C)C)OC3=C(C4=C(C=C3)C(=C(C(=O)O4)NC(=O)C5=CNC(=C5C)C(=O)NC6=C(C7=C(C(=C(C=C7)OC8C(C(C(C(O8)(C)C)OC)OC(=O)C9=CC=C(N9)C)O)C)OC6=O)O)O)C)O

InChi: InChI=1S/C55H59N5O20/c1-21-12-16-29(57-21)48(67)77-42-38(63)52(79-54(6,7)44(42)71-10)73-31-18-14-26-36(61)34(50(69)75-40(26)24(31)4)59-46(65)28-20-56-33(23(28)3)47(66)60-35-37(62)27-15-19-32(25(5)41(27)76-51(35)70)74-53-39(64)43(45(72-11)55(8,9)80-53)78-49(68)30-17-13-22(2)58-30/h12-20,38-39,42-45,52-53,56-58,61-64H,1-11H3,(H,59,65)(H,60,66)/t38-,39-,42+,43+,44-,45-,52-,53-/m1/s1

InChi Key: WTIJXIZOODAMJT-DHFGXMAYSA-N