Coumestrol | B3273

Coumestrol is naturally occurring phytoestrogen. It competitively binds the estrogen receptors ERα (IC50 = 11 nM) and ERβ (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells. Coumestrol also acts as a weak antagonist of pregnane X receptor (IC50 = 12 μM) as well as a potential inverse agonist of the constitutive androstane receptor (EC50 = 30 μM).

Coumestrol is naturally occurring phytoestrogen. It competitively binds the estrogen receptors ERα (IC50 = 11 nM) and ERβ (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells. Coumestrol also acts as a weak antagonist of pregnane X receptor (IC50 = 12 μM) as well as a potential inverse agonist of the constitutive androstane receptor (EC50 = 30 μM).

B3273 | Coumestrol DataSheet

Alternate Name/Synonyms: 3,9-dihydroxy-6H-benzofuro[3,2-c][1]benzopyran-6-one NSC-22842

Appearance: White to off-white solid

Formulation:

CAS Number: 479-13-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₈O₅

Molecular Weight: 268.22

Cell-Permeable?: True

Purity: ≥98%

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A biologically active phytoestrogen

MDL Number: MFCD00016885

PubChem CID: 5281707

SMILES: O=C1OC2=C(C=CC(O)=C2)C3=C1C4=CC=C(O)C=C4O3

InChi: InChI=1S/C15H8O5/c16-7-1-3-9-11(5-7)19-14-10-4-2-8(17)6-12(10)20-15(18)13(9)14/h1-6,16-17H

InChi Key: ZZIALNLLNHEQPJ-UHFFFAOYSA-N