Cox-11 (F80) polyclonal Antibody | BS2185

Cox-11 (F80) polyclonal Antibody | BS2185 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: Cytochrome c oxidase (COX) is the terminal enzyme in the electron transfer chain, functioning as a transmembrane proton pump that builds an electrochemical gradient with chemical energy from the reduction of O2. Cytochrome c oxidase assembly protein COX11 is an intracellular mitochondrial membrane protein necessary for the construction of an active COX complex. COX11 contains a single transmembrane helix downstream of the N-terminal, mitochondrial targeting sequence and a C-terminal Cu (I) -binding domain. The assembly of COX requires the delivery of metal cofactors. Along with COX12 and SCO1/2, COX11 acts as a metal ion chaperone necessary for copper insertion into CuA and CuB redox-active copper centers of COX in eukaryotes.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Cox-11 (F80) polyclonal Antibody detects endogenous levels of Cox-11 protein.

Molecular Weight: ~ 31 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cytochrome c oxidase assembly protein COX11, mitochondrial; COX11

Immunogen: Synthetic peptide, corresponding to amino acids 50-100 of Human Cox-11.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: AMPK Signaling Pathway,