Cox2 Antibody | 14-486

Cox2 Antibody | 14-486 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 375-604 of human Cox2 (NP_000954.1) .

Research Area: Cancer, Signal Transduction

Tested Application: WB, IHC, IF, IP

Application: WB: 1:1000 - 1:4000
IHC: 1:50 - 1:100
IF: 1:50 - 1:100
IP: 1:50 - 1:100

Specificiy: N/A

Positive Control 1: A-549

Positive Control 2: HeLa

Positive Control 3: Mouse spleen

Positive Control 4: Mouse lung

Positive Control 5: Rat lung

Positive Control 6: Rat kidney

Molecular Weight: Observed: 80kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: COX-2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) , COX2, COX-2, PHS-2, PGG/HS, PGHS-2, hCox-2, prostaglandin G/H synthase and cyclooxygenase

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Prostaglandin-endoperoxide synthase (PTGS) , also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.