COX2 polyclonal Antibody | BS90326

COX2 polyclonal Antibody | BS90326 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: WB ICC/IF

Application Range: WB:1:1,000-1:5,000 ICC:1:50-1:200

Background: Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA) . Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS) . Cox-1 is constitutively expressed in most tissues and is thought to serve in general “housekeeping” functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: COX2 polyclonal Antibody detects endogenous levels of COX2 protein.

Molecular Weight: 72 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: COX-2, PGH synthase 2, PGHS-2, PTGS2, COX 2, COX-2, COX2, Cyclooxygenase 2, Cyclooxygenase 2b, Cyclooxygenase, Cyclooxygenase-2, Cyclooxygenase2, EC 1.14.99.1, fj02a10, Glucocorticoid-regulated inflammatory cyclooxygenase, Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase, GRIPGHS, hCox 2, Macrophage activation-associated marker protein P71/73, OTTHUMP00000033524, PES-2, PGG/HS, PGH synthase 2, PGH2, PGHS 2, PGHS-2, PGHS2, PHS 2, PHS II, PHS2, Prostaglandin endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), Prostaglandin endoperoxide synthase 2, Prostaglandin G/H synthase 2, Prostaglandin G/H synthase 2 precursor, Prostaglandin G/H synthase and cyclooxygenase, Prostaglandin G/H synthase, Prostaglandin H2 synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), Prostaglandin-endoperoxide synthase 2, PTGS2, ptgs2a, TIS10, TIS10 protein, unp1239, wu:fj02a10,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: