CP-31398 Dihydrochloride | 1815

A styrylquinazoline derivative that acts as a p53 stabilizing agent. It not only restores p53 functions in mutant p53-expressing cells but can also significantly increase the protein level and promote the activity of wild-type p53 in multiple human cancer cell lines, leading to cell cycle arrest or apoptosis. CP-31398 enhances the protein levels of wild-type p53 by blockade of ubiquitination and degradation of p53 without interrupting the physical association between p53 and MDM2 in vivo.

CP-31398 Dihydrochloride is a styrylquinazoline derivative that acts as a p53 stabilizing agent. It not only restores p53 functions in mutant p53-expressing cells but can also significantly increase the protein level and promote the activity of wild-type p53 in multiple human cancer cell lines, leading to cell cycle arrest or apoptosis.

1815 | CP-31398 Dihydrochloride DataSheet

Alternate Name/Synonyms: N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine Dihydrochloride

Appearance: Yellow solid

Formulation: N/A

CAS Number: 1217195-61-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₆N₄O.2HCl

Molecular Weight: 435.39

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: H₂O (25 mg/ml) or DMSO (5 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A p53 stabilizing agent

MDL Number: MFCD17215956

PubChem CID: 9950868

SMILES: CN(C)CCCNC1=NC(=NC2=CC=CC=C21)C=CC3=CC=C(C=C3)OC

InChi: InChI=1S/C22H26N4O/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25)/b14-11+

InChi Key: NIHSNFSFDGHHRG-SDNWHVSQSA-N